Favourite Thing: build step by step the knowledge basis for understanding how biological systems work
2nd Athens Lykeio (sixth form college), Greece, 1978-1981
1981-1986 studied Chemistry at the Aristotelian University of Thessaloniki, Greece; 1986-1987 Masters in Microbiology at University Paris VII, France; 1988-1992 PhD in Molecular Biology at the Biozentrum, University of Basel, Switzerland
Department of Vitamins and Fine Chemicals, Hoffmann-La Roche Ltd, Basel, Switzerland and Welccome Trust Sanger Institute
Area of Research:
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Me and my work
Research how genes predispose us to disease in particular heart disease or affect our response to drugs
I am heading a group of 14 people working on the genetics of common diseases in humans and in particular coronary artery disease (CAD) and myocardial infarction (MI). We asseble very large collections of CAD / MI patients (cases) and individuals without the disease (controls) and then scan their genomes at polymorpic sites to identify DNA changes that differ in frequency between the two groups and this is statistically significant. There are several known risk factors for CAD such as family history, high lipid levels, high blood pressure, diabetes, and smoking so in parallel we conduct studies in the normal population looking for DNA changes that mark for example high cholesterol and we then go go back to test them in case-control studies. The first findings though only represent disease ‘markers’ we don’t actually know which gene and DNA change are disease causing. So we have to perform functional tests for example check whether a DNA change affects the transcription of a gene or give rise to a protein with altered properties. Work in model organisms such as mouse and zebra fish where it is possible to ‘knock out’ a gene give vital clues as to how a gene of interest functions. But genetic factors is not the whole story and therefore we also investigate epigenetic changes for example there are DNA sites that are methylated and methylation levels vary between individuals. Finally, we know that the environment plays a major role in disease and we want to undersytand how genetic and environmental factors interact.
My Typical Day
starts by reading my emails and carries on with activities such as participarion in tele conferences and meetings, discussions with my co-workers about the ongoing research projects and reviwing our results
Genome sequencing and my research
Genetic studies is all about differences for example comparing those who suffer a heart attack and those who don’t; genome sequencing is the tool to test systematically every DNA base for risk
How would you describe yourself in 3 words?
open minded, methodical, determined
What music do you have on your iPod?
jazz, classical, rock
What is the most fun thing you've done?
What do you like to do away from work?
going to a restaurant (love good food), philately, watching movies
What did you want to be after you left school?
Were you ever in trouble in at school?
What's the best thing you've done as a scientist?
complete two of the chromosomes in the Human Genome Project