Favourite Thing: I want to find a cure for osteoporosis one day, and I am working hard to reach there.
Saraswati Sishu Mandir (Lucknow, India)
University of Lucknow (Lucknow, India): B.Sc. Biology (1994-97), M.Sc. Biochemistry (1997-99). Indian Institute of Science (Bangalore, India) : Ph.D. in Molecular Endocrinology (1999-2005)
After Ph.D. in understanding how ovaries function in mammals I worked at Baylor College of Medicine, USA (2005-2006) and then Columbia University, New York, USA (2006-2010) as a scientist
Mouse and Zebrafish Genetics
Area of Research:
Find out more:
I am interested in how skeleton, one of the largest organs in our bodies, functions. I do this by using mouse as a model to remove genes and study what effect does it have on skeleton.
Me and my work
I use mouse as a model to understand human skeleton, and try finding new ways to cure skeletal diseases viz., osteoporosis and arthritis.
I work on bones. The bones in our body are like houses. A house is constantly deteriorating due to external factors, such as sunlight and rain, internal factors such as rusting or woodworm. In the same way our bones can deteriorate due to factors that originate within and outside the bone. For example, alterations in the levels and/or action of molecules (hormones) can lead to changes in bone mass. The best example of this phenomenon is the loss of oestrogen – an ovary-derived hormone – after menopause, which can lead to osteoporosis. I aim to identify some of these factors that regulate bone through the use of genomic and proteomic approaches. This may help to further the understanding of the biology of bone and ultimately identify new targets for to cure bone diseases.
My Typical Day
Bus to work, email, do experiments, talk to group members, do more experiments, grab a quick lunch in between, drink a coke, write, think and brainstorm the ideas.
Genome sequencing and my research
Genome sequencing (RNA and DNA) has identified how many genes and proteins are there and when they are expressed, my group uses this information to link genes expressed in distant organs.
How would you describe yourself in 3 words?
Determined, Analytical, Optimist
What music do you have on your iPod?
I don’t classify music, I love listening to whatever feels good. I have Pink Floyd songs, Yoga chants and Shlokas, Sufi songs, Bollywood songs etc.,
What is the most fun thing you've done?
Climbed a hill, starting at 3AM in the morning, to see the sunrise from the hill top while sipping a cup of coffee.
What do you like to do away from work?
What did you want to be after you left school?
Were you ever in trouble in at school?
What's the best thing you've done as a scientist?
Identified that serotonin coming from the gut regulates how much bone we deposit, this has a potential to cure osteoporosis by inhibiting its production.